Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140

نویسندگان

  • Vincent Cavaillès
  • Marion Lapierre
چکیده

Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.

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عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2014